Gene therapy for the treatment of mitochondrial DNA disorders

  title={Gene therapy for the treatment of mitochondrial DNA disorders},
  author={R. Taylor},
  journal={Expert Opinion on Biological Therapy},
  pages={183 - 194}
  • R. Taylor
  • Published 2005
  • Biology, Medicine
  • Expert Opinion on Biological Therapy
  • Despite recent epidemiological studies confirming that mitochondrial respiratory chain disorders due to mutations in either the mitochondrial or nuclear genome are amongst the most common inherited human diseases, realistic therapeutic strategies for these patients remain limited. The disappointing response to various vitamins, cofactors and electron acceptors that have been administered to patients in an attempt to bypass the underlying respiratory chain defect, coupled with the complexities… CONTINUE READING
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