Gene therapy for rheumatoid arthritis

  title={Gene therapy for rheumatoid arthritis},
  author={A. Reinhardt and R. Hirsch},
  journal={Future Rheumatology},
  • A. Reinhardt, R. Hirsch
  • Published 2007
  • Medicine
  • Future Rheumatology
  • Therapy for rheumatoid arthritis (RA) has seen significant advances over the past decade. The use of biologic agents, such as TNF-α inhibitors, have led to improvement in up to 60% of RA patients. Unfortunately, biologic therapy also presents significant limitations, including systemic side effects, a short half-life with requirement for frequent dosing, and a lack of curative response. Owing to such limitations, the ideal therapy for RA remains unrealized. Progress in the field of gene therapy… CONTINUE READING

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    • 13
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