Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.

@article{Aoki1997GeneTF,
  title={Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.},
  author={Kazunori Aoki and Teruhiko Yoshida and Naoko Matsumoto and Hisamitsu Ide and Kazuyuki Hosokawa and Takashi Sugimura and Masaaki Terada},
  journal={Human gene therapy},
  year={1997},
  volume={8 9},
  pages={1105-13}
}
Peritoneal dissemination is one of the most common complications of the malignancies of the digestive system, such as gastric or pancreatic cancers. Yet, no effective therapy has been established so far to alleviate this devastating and often fatal end-stage condition. Here we describe a novel approach of intraperitoneal (i.p.) lipofection of a suicidal gene to the pancreatic cancer cells in a mouse peritoneal dissemination model. A human pancreatic cancer cell line, PSN-1, was inoculated into… CONTINUE READING