Gene therapy for ovarian carcinoma.

  title={Gene therapy for ovarian carcinoma.},
  author={Michael W. Robertson and Mack N. Barnes and Claudine Rancourt and Minghui Wang and Jonathan E. Grim and Ronald D. Alvarez and Gene P. Siegal and David T. Curiel},
  journal={Seminars in oncology},
  volume={25 3},
Originally conceived and applied for the treatment of inherited monogenetic defects such as adenosine deaminase deficiency and cystic fibrosis, gene therapy was later applied to the treatment of cancer. Such a genetic strategy seemed rational given the recognition that cancer typically develops in a multistep process involving alterations of a number of different genes as demonstrated in familial polyposis and colorectal cancer through the work of Vogelstein et al. Because of the numerous… CONTINUE READING