Gene therapy for optic nerve disease

  title={Gene therapy for optic nerve disease},
  author={Keith R Martin and Harry A. Quigley},
AbstractPurpose There has been recent interest in the potential use of gene therapy techniques to treat ocular disease. In this article, we consider the optic nerve diseases that are potentially most amenable to gene therapy.Methods We discuss the recent success of gene transfer experiments in animal models of glaucoma, optic neuritis, Leber's hereditary optic neuropathy (LHON), and optic nerve transection, and we assess the possibility of using similar techniques to treat human disease in the… CONTINUE READING


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High efficiency transfection of rat retinal ganglion cells by a modified adenoassociated virus incorporating the woodchuck hepatitis post - transcriptional regulatory element

KR Martin, RL Klein, +3 authors ME Pease
Invest Ophthalmol Vis Sci ( ARVO Abstract ) • 2002

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