Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia.

@article{Losordo1998GeneTF,
  title={Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia.},
  author={Douglas W. Losordo and Peter R. Vale and James F. Symes and Cheryl H. Dunnington and Darryl D. Esakof and Michael Maysky and Alan B. Ashare and Kishor G Lathi and Jeffrey M. Isner},
  journal={Circulation},
  year={1998},
  volume={98 25},
  pages={2800-4}
}
BACKGROUND We initiated a phase 1 clinical study to determine the safety and bioactivity of direct myocardial gene transfer of vascular endothelial growth factor (VEGF) as sole therapy for patients with symptomatic myocardial ischemia. METHODS AND RESULTS VEGF gene transfer (GTx) was performed in 5 patients (all male, ages 53 to 71) who had failed conventional therapy; these men had angina (determined by angiographically documented coronary artery disease). Naked plasmid DNA encoding VEGF… CONTINUE READING
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