Gene therapy for murine glycerol kinase deficiency: importance of murine ortholog.

Abstract

A glycerol kinase (Gyk) knock-out (KO) mouse model permits improved understanding of glycerol kinase (GK) deficiency (GKD) pathogenesis, however, early death of affected mice limits its utility. The purpose of this work was to delay death of affected males to investigate thoroughly their phenotypes. An adenoviral vector carrying the human (Adeno-XGK) or… (More)

Topics

  • Presentations referencing similar topics