Gene therapy for human cancer: an essay for clinicians.

  title={Gene therapy for human cancer: an essay for clinicians.},
  author={Michael J. Mastrangelo and David Berd and Faith E Nathan and Edmund C. Lattime},
  journal={Seminars in oncology},
  volume={23 1},
In the last decade our understanding of the processes that govern growth and differentiation has become quite sophisticated. A variety of tumor suppressor genes and more than 100 oncogenes have been identified. The roles of developmental genes in shaping the expression of neoplasia and of defective housekeeping genes in allowing mutations to persist and be transcribed have been appreciated. These advances have revolutionized our ability to diagnose and to formulate prognoses for patients with… CONTINUE READING

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