Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter.

@article{Ido1995GeneTF,
  title={Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter.},
  author={Akira Ido and Keisuke Nakata and Yukihiko Kato and Kazuhiko Nakao and K. Murata and Manabu Fujita and Nobuko Ishii and T. Tamaoki and Hiroshi Shiku and Shigenobu Nagataki},
  journal={Cancer research},
  year={1995},
  volume={55 14},
  pages={3105-9}
}
The alpha-fetoprotein (AFP) gene is normally expressed in fetal liver and is transcriptionally silent in adult liver but is reactivated in hepatocellular carcinoma. It has been shown that the positive and negative transcriptionally regulatory elements of the human AFP gene, which play an important role in its developmental regulation, exist over the quite extended region (4 kb). We constructed a hybrid gene consisting of herpes simplex virus thymidine kinase (HSV-tk) gene under the control of… CONTINUE READING

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