Gene therapy for chronic pain.

  title={Gene therapy for chronic pain.},
  author={Joseph Charles Glorioso and Marina Mata and David J. Fink},
  journal={Current opinion in molecular therapeutics},
  volume={5 5},
The dorsal horn of the spinal cord represents an attractive site for interventions designed to treat chronic pain, but it has been difficult to identify small molecules that act selectively on pain transmission at the spinal level. One approach is the use of viral vector-mediated gene transfer to achieve focal production and release of short-lived analgesic peptides. Herpes simplex virusbased vectors, expressing proenkephalin delivered by subcutaneous inoculation, transduce neurons of the… CONTINUE READING

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