Gene therapy for chondral and osteochondral regeneration: is the future now?

@article{Bellavia2017GeneTF,
  title={Gene therapy for chondral and osteochondral regeneration: is the future now?},
  author={Daniele Bellavia and Francesca Veronesi and Valeria Carina and Viviana Costa and Lavinia Raimondi and Angela De Luca and Horace Andrew Husay and Milena Fini and Gianluca Giavaresi},
  journal={Cellular and Molecular Life Sciences},
  year={2017},
  volume={75},
  pages={649-667}
}
Gene therapy might represent a promising strategy for chondral and osteochondral defects repair by balancing the management of temporary joint mechanical incompetence with altered metabolic and inflammatory homeostasis. This review analysed preclinical and clinical studies on gene therapy for the repair of articular cartilage defects performed over the last 10 years, focussing on expression vectors (non-viral and viral), type of genes delivered and gene therapy procedures (direct or indirect… CONTINUE READING

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