Gene therapy for articular cartilage repair.

  title={Gene therapy for articular cartilage repair.},
  author={Stephen B. Trippel and Magali Cucchiarini and Henning Madry and Shuiliang Shi and Chunbo Wang},
  journal={Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine},
  volume={221 5},
Articular cartilage serves as the gliding surface of joints. It is susceptible to damage from trauma and from degenerative diseases. Restoration of damaged articular cartilage may be achievable through the use of cell-regulatory molecules that augment the reparative activities of the cells, inhibit the cells' degradative activities, or both. A variety of such molecules have been identified. These include insulin-like growth factor I, fibroblast growth factor 2, bone morphogenetic proteins 2, 4… CONTINUE READING


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