Gene therapy approaches for bone regeneration.

  title={Gene therapy approaches for bone regeneration.},
  author={Renny T. Franceschi and Shuying Yang and Robert B. Rutherford and Paul H Krebsbach and Ming Peng Zhao and Dian Wang},
  journal={Cells, tissues, organs},
  volume={176 1-3},
Gene therapy represents a promising approach for delivering regenerative molecules to specific tissues including bone. Several laboratories have shown that virus-based BMP expression vectors can stimulate osteoblast differentiation and bone formation in vivo. Both in vivo and ex vivo transduction of cells can induce bone formation at ectopic and orthotopic sites. Adenovirus and direct DNA delivery of genes encoding regenerative molecules can heal critical-sized defects of cranial and long bones… CONTINUE READING
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