Gene therapy and cement injection for restabilization of loosened hip prostheses.

@article{Poorter2008GeneTA,
  title={Gene therapy and cement injection for restabilization of loosened hip prostheses.},
  author={Jolanda J. de Poorter and Rob C Hoeben and Simone Hogendoorn and Vivien Mautner and John W. Ellis and Wim R. Obermann and Tom W. J. Huizinga and Rob G. H. H. Nelissen},
  journal={Human gene therapy},
  year={2008},
  volume={19 1},
  pages={83-95}
}
Loosening of orthopedic hip prostheses is an increasing health problem. In elderly patients with comorbidity,revision surgery may lead to high mortality rates. A less invasive surgical technique is therefore required to reduce these patient risks. To this end a percutaneous gene therapy approach was designed to destroy the periprosthetic loosening membrane, and enable refixing of the hip prosthesis with percutaneous bone cement injections under radiological guidance. In this phase 1/2 dose… CONTINUE READING

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