Gene therapy against an experimental glioma using adeno-associated virus vectors.

  title={Gene therapy against an experimental glioma using adeno-associated virus vectors.},
  author={Hiroshi Okada and Koichi Miyamura and Takeysohi Itoh and Masaru Hagiwara and Tomo Wakabayashi and Masaaki Mizuno and Peter Colosi and G Kurtzman and Jun Yoshida},
  journal={Gene therapy},
  volume={3 11},
The efficacy of gene therapy for glioma was examined using adeno-associated virus (AAV)-based vectors to deliver genes to experimental tumors in mice. Stereotactic injection of 2 x 10(5) U-251SP human glioma cells into the brains of nude mice produced tumors of 19.06 +/- 1.79 mm2 17 days after injection. Employing a high titer preparation of AAV vector containing the gene for beta-galactosidase (AAV-lacZ), dose-dependent transduction of U-251SP cells was seen in vitro. When 1.6 x 10(10) AAV… CONTINUE READING


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