Gene therapy: X-SCID transgene leukaemogenicity

@article{Thrasher2006GeneTX,
  title={Gene therapy: X-SCID transgene leukaemogenicity},
  author={Adrian James Thrasher and H Bobby Gaspar and Christopher Baum and Ute Modlich and Axel Schambach and Fabio Candotti and Makoto Otsu and Brian P. Sorrentino and Linda Scobie and Ewan R Cameron and Karen Blyth and Jim Neil and Salima Hacein-Bey Abina and Marina Cavazzana‐Calvo and Alain Fischer},
  journal={Nature},
  year={2006},
  volume={443},
  pages={E5-E6}
}
Arising from: Woods, N.-B., Bottero, V., Schmidt, M., von Kalle, C. & Verma, I. M. 440, 1123 (2006); see also communication from Pike-Overzet et al.; Woods et al. replyGene therapy has been remarkably effective for the immunological reconstitution of patients with severe combined immune deficiency, but the occurrence of leukaemia in a few patients has stimulated debate about the safety of the procedure and the mechanisms of leukaemogenesis. Woods et al. forced high expression of the corrective… Expand
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  • Biology, Medicine
  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2009
TLDR
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