Gene therapy: Therapeutic gene causing lymphoma

  title={Gene therapy: Therapeutic gene causing lymphoma},
  author={N. Woods and Virginie Bottero and M. Schmidt and C. Kalle and I. Verma},
  • N. Woods, Virginie Bottero, +2 authors I. Verma
  • Published 2006
  • Biology, Medicine
  • Nature
  • The development of T-cell leukaemia following the otherwise successful treatment of three patients with X-linked severe combined immune deficiency (X-SCID) in gene-therapy trials using haematopoietic stem cells has led to a re-evaluation of this approach. Using a mouse model for gene therapy of X-SCID, we find that the corrective therapeutic gene IL2RG itself can act as a contributor to the genesis of T-cell lymphomas, with one-third of animals being affected. Gene-therapy trials for X-SCID… CONTINUE READING
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