Gene therapy: Therapeutic gene causing lymphoma
@article{Woods2006GeneTT, title={Gene therapy: Therapeutic gene causing lymphoma}, author={N. Woods and Virginie Bottero and M. Schmidt and C. Kalle and I. Verma}, journal={Nature}, year={2006}, volume={440}, pages={1123-1123} }
The development of T-cell leukaemia following the otherwise successful treatment of three patients with X-linked severe combined immune deficiency (X-SCID) in gene-therapy trials using haematopoietic stem cells has led to a re-evaluation of this approach. Using a mouse model for gene therapy of X-SCID, we find that the corrective therapeutic gene IL2RG itself can act as a contributor to the genesis of T-cell lymphomas, with one-third of animals being affected. Gene-therapy trials for X-SCID… CONTINUE READING
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- Biology
- Nature
- 2006
- 4
Assessing the risk of T-cell malignancies in mouse models of SCID-X1.
- Biology, Medicine
- Molecular therapy : the journal of the American Society of Gene Therapy
- 2010
- 6
[Gene therapy of SCID-X1].
- Medicine
- Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
- 2007
- 6
Gene therapy for primary immunodeficiencies.
- Medicine
- Immunology and allergy clinics of North America
- 2008
- 10
Safer vectors for gene therapy of primary immunodeficiencies.
- Biology, Medicine
- Current gene therapy
- 2009
- 3
- PDF
Sola dosis facit venenum. Leukemia in gene therapy trials: a question of vectors, inserts and dosage?
- Biology, Medicine
- Leukemia
- 2008
- 23
- PDF
Combating oncogene activation associated with retrovirus-mediated gene therapy of X-linked severe combined immunodeficiency
- Medicine
- 2007
- 2
- PDF
New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy.
- Biology, Medicine
- Molecular therapy : the journal of the American Society of Gene Therapy
- 2007
- 95
References
SHOWING 1-10 OF 12 REFERENCES
LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1
- Biology, Medicine
- Science
- 2003
- 3,269
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.
- Medicine
- The New England journal of medicine
- 2002
- 1,069
Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach.
- Biology, Medicine
- Blood
- 1999
- 76
Lymphoid development and function in X-linked severe combined immunodeficiency mice after stem cell gene therapy.
- Biology, Medicine
- Molecular therapy : the journal of the American Society of Gene Therapy
- 2000
- 61
Lack of dominant-negative effects of a truncated gamma(c) on retroviral-mediated gene correction of immunodeficient mice.
- Biology, Medicine
- Blood
- 2001
- 20
- PDF
In vivo competitive studies between normal and common gamma chain-defective bone marrow cells: implications for gene therapy.
- Medicine, Biology
- Human gene therapy
- 2000
- 17
The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice.
- Biology, Medicine
- Oncogene
- 1995
- 90
Stable and functional lymphoid reconstitution of common cytokine receptor gamma chain deficient mice by retroviral-mediated gene transfer.
- Biology, Medicine
- Blood
- 2000
- 95
Lentivirus Vector-Mediated Hematopoietic Stem Cell Gene Transfer of Common Gamma-Chain Cytokine Receptor in Rhesus Macaques
- Biology, Medicine
- Journal of Virology
- 2001
- 75
- PDF