Gene targeting in the mouse.

  title={Gene targeting in the mouse.},
  author={David W. Melton},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={16 9},
  • David W. Melton
  • Published 1994 in
    BioEssays : news and reviews in molecular…
Mice with alterations to specific endogenous genes can be produced by gene targeting in embryonic stem cells. The field has developed rapidly over the past decade, so that large numbers of mice with different gene deficiencies have been generated. Knockout mice provide an ideal opportunity to analyse the function of individual mammalian genes and to model a range of human inherited disorders. This powerful approach has also identified numerous examples of gene redundancy and has highlighted the… CONTINUE READING