Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling.

@article{Yeh1999GeneTI,
  title={Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling.},
  author={Wen-chen Yeh and Razqallah Hakem and Minna Woo and Tak W Mak},
  journal={Immunological reviews},
  year={1999},
  volume={169},
  pages={283-302}
}
Apoptosis, or programmed cell death (PCD), is the subject of much current investigative interest. Developing embryos and many adult organ systems require the tight coupling of cellular proliferation and PCD to ensure proper organogenesis and optimal tissue function. Over the past decade, our knowledge of the genetic basis underlying the execution of apoptosis in mammals has progressed enormously, thanks largely to groundbreaking studies performed in the nematode Caenorhabditis elegans. In… CONTINUE READING

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