Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis.

@article{Denham1997GeneTD,
  title={Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis.},
  author={Woody Denham and Jun Yang and George Fink and Daphne W Denham and Gay L. Carter and Keith A. Ward and James C Norman},
  journal={Gastroenterology},
  year={1997},
  volume={113 5},
  pages={1741-6}
}
BACKGROUND & AIMS During severe pancreatitis, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha are produced in large quantities. The aim of this study was to determine whether either one plays a more dominant role and if their detrimental effects are additive. METHODS Necrotizing pancreatitis was induced in transgenic (-/-) knockout mice deficient in either IL-1 type 1 receptors, TNF type 1 receptors, or both IL-1 and TNF type 1 receptors. Wild-type mice served as controls… CONTINUE READING

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