Gene targeting by adeno-associated virus vectors is cell-cycle dependent.

@article{Trobridge2005GeneTB,
  title={Gene targeting by adeno-associated virus vectors is cell-cycle dependent.},
  author={Grant D. Trobridge and Roli K. Hirata and David W. Russell},
  journal={Human gene therapy},
  year={2005},
  volume={16 4},
  pages={
          522-6
        }
}
Adeno-associated virus (AAV) vectors can be used to introduce site-specific mutations into homologous chromosomal sequences. There are many potential applications of this technique, but the process of AAV-mediated gene targeting and factors that influence targeting efficiency are not completely understood. We investigated the dependence of AAV-mediated gene targeting on the host cell-cycle status. The frequency of gene targeting by AAV vectors was compared in dividing and serum-arrested normal… CONTINUE READING

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