Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.

Abstract

TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3'-->5' exonuclease that is widely distributed in both proliferating and nonproliferating mammalian tissues. The cognate cDNA shows homology to the editing subunit of the Escherichia coli replicative DNA polymerase III holoenzyme and encodes an exonuclease which was able to… (More)

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@article{Morita2004GenetargetedML, title={Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.}, author={Masashi Morita and Gordon Stamp and Peter Robins and Anna Dulic and Ian R. Rosewell and Geza Hrivnak and Graham Daly and Tomas L Lindahl and Deborah E. Barnes}, journal={Molecular and cellular biology}, year={2004}, volume={24 15}, pages={6719-27} }