Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.

@article{Morita2004GenetargetedML,
  title={Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.},
  author={Masashi Morita and Gordon Stamp and Pj. Robins and Anna Dulic and Ian R. Rosewell and Geza Hrivnak and Graham Daly and T. Lindahl and Deborah E. Barnes},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 15},
  pages={
          6719-27
        }
}
TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3'-->5' exonuclease that is widely distributed in both proliferating and nonproliferating mammalian tissues. The cognate cDNA shows homology to the editing subunit of the Escherichia coli replicative DNA polymerase III holoenzyme and encodes an exonuclease which was able to serve a DNA-editing function in vitro, promoting rejoining of a 3' mismatched residue in a reconstituted DNA base excision repair system… CONTINUE READING
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