Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection.

@article{Weid1996GenetargetedML,
  title={Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection.},
  author={Thierry von der Weid and N Honarvar and Jean Langhorne},
  journal={Journal of immunology},
  year={1996},
  volume={156 7},
  pages={2510-6}
}
Mice deficient of mature B cells due to a targeted disruption of the transmembrane exon of the Ig mu-chain gene (mu-MT mice) can reduce a primary acute infection with the malaria parasite Plasmodium chabaudi chabaudi (AS strain) to low levels but are unable to eliminate parasites and instead develop chronic relapsing parasitemias. This model of B cell deficiency confirms previous findings using anti-mu-treated mice that B cells are required for final parasite clearance. Injection of B cells… CONTINUE READING