Gene switching at Xenopus laevis metamorphosis.

  title={Gene switching at Xenopus laevis metamorphosis.},
  author={Sandeep Mukhi and Liquan Cai and Donald D. Brown},
  journal={Developmental biology},
  volume={338 2},
During the climax of amphibian metamorphosis many tadpole organs remodel. The different remodeling strategies are controlled by thyroid hormone (TH). The liver, skin, and tail fibroblasts shut off tadpole genes and activate frog genes in the same cell without DNA replication. We refer to this as "gene switching". In contrast, the exocrine pancreas and the intestinal epithelium dedifferentiate to a progenitor state and then redifferentiate to the adult cell type. Tadpole and adult globin are not… CONTINUE READING

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