Gene structure of the human receptor tyrosine kinase RON and mutation analysis in lung cancer samples.

@article{Angeloni2000GeneSO,
  title={Gene structure of the human receptor tyrosine kinase RON and mutation analysis in lung cancer samples.},
  author={Debora Angeloni and Alla Danilkovitch-Miagkova and Sergey V. Ivanov and R. Breathnach and Bruce Evan Johnson and Edward J. Leonard and M. I. Lerman},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={29 2},
  pages={147-56}
}
The human RON gene (MST1R) maps to 3p21.3, a region frequently altered in lung cancer and other malignancies. It encodes a receptor tyrosine kinase (RTK) closely related to MET, whose mutations are associated with neoplasia. We investigated whether RON might be involved in the development or progression of lung cancer. We first determined the exon-intron structure of the gene by direct sequencing of RON cosmid DNA and PCR products containing intronic sequences, and then developed primers… CONTINUE READING

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