Gene structure of the Kiss1 receptor-2 (Kiss1r-2) in the Atlantic halibut: insights into the evolution and regulation of Kiss1r genes.

@article{Mechaly2010GeneSO,
  title={Gene structure of the Kiss1 receptor-2 (Kiss1r-2) in the Atlantic halibut: insights into the evolution and regulation of Kiss1r genes.},
  author={Alejandro S. Mechaly and Jordi Vi{\~n}as and Colleen L Murphy and Michael E. Reith and Francesc Piferrer},
  journal={Molecular and cellular endocrinology},
  year={2010},
  volume={317 1-2},
  pages={78-89}
}
Kisspeptin and its receptor, Kiss1r, play an essential role in the control of the onset of puberty in vertebrates. We characterized the cDNA and genomic DNA encoding Kiss1r in Atlantic halibut (Hippoglossus hippoglossus). The 1146bp open reading frame predicts a 381 amino acid protein with high homology to the Kiss1r-2 of other teleost fish. Phylogenetic analysis of Kiss1r sequences suggests that the mammalian Kiss1r-1 form arose by way of a gene duplication prior to the emergence of amphibians… CONTINUE READING