Gene structure and chromosomal assignment of mouse GITR, a member of the tumor necrosis factor/nerve growth factor receptor family.

@article{Nocentini2000GeneSA,
  title={Gene structure and chromosomal assignment of mouse GITR, a member of the tumor necrosis factor/nerve growth factor receptor family.},
  author={G. Nocentini and A. Bartoli and S. Ronchetti and L. Giunchi and A. Cupelli and D. Delfino and G. Migliorati and C. Riccardi},
  journal={DNA and cell biology},
  year={2000},
  volume={19 4},
  pages={
          205-17
        }
}
GITR is a type I transmembrane protein that belongs to the tumor necrosis factor/nerve growth factor receptor (TNF/NGFR) family. This receptor is preferentially expressed in activated T lymphocytes and may function as signaling molecule during T-cell development. In the present study, we examined the genomic organization of the entire mouse GITR (mGITR) gene. The gene spans a 2543-bp region and consists of five exons (with a length ranging from 88 bp to 395 bp) and four introns (67 bp to 778 bp… Expand
Structural basis for ligand-mediated mouse GITR activation
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It is hypothesized that specific oligomeric forms of GITRL may be used as a means to differentially control GITR receptor signaling in diverse cells through C terminus-mediated conformational changes. Expand
The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis
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Examination of evidence for non-immunological roles of TNFRSF members in brain development, function and maintenance under normal physiological conditions finds several aspects of brain function during inflammation will also be described, when illuminating and relevant to the non-IMmunological role of TNSF members. Expand
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GITR interacts with the pro-apoptotic protein Siva and induces apoptosis
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The Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related Gene Modulates the Response to Candida albicans Infection
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Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
TLDR
The results show that the proliferation response of CD8+ and CD4+ peripheral T cell subpopulations was potentiated when a GITR costimulus was added to an anti‐CD3 stimulus, suggesting a novel function for G ITR as costimulatory molecule of T cell subsets. Expand
Glucocorticoid-Induced TNF Receptor Expression by T Cells Is Reciprocally Regulated by NF-κB and NFAT1
TLDR
It is proposed that two major transcriptional factors activated downstream of the TCR, namely, NF-κB and NFAT, act reciprocally to balance TCR-mediated GITR expression in conventional T cells, an outcome that appears to influence cell survival. Expand
TISSUE DISTRIBUTION OF GITR AND GITRL GITR Is Mainly Expressed in T and Natural Killer Cells
Glucocorticoid-induced TNFR-Related (GITR) protein is a member of the tumor necrosis factor receptor superfamily that modulates acquired and natural immune response. It is expressed in several cellsExpand
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