Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

@article{Bouillet2001GeneSA,
  title={Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim},
  author={Philippe Bouillet and Li Zhang and David C.S. Huang and Graham C. Webb and Cynthia D. K. Bottema and P. Shore and Helen J. Eyre and Grant R. Sutherland and Jerry M. Adams},
  journal={Mammalian Genome},
  year={2001},
  volume={12},
  pages={163-168}
}
Bim is a proapoptotic protein of the Bcl-2 family that shares only the short BH3 domain with other members. It has three isoforms, apparently produced by alternative splicing. The demonstration that Bim is essential for certain apoptotic responses and to prevent overproduction of hematopoietic cells suggests that it may be a tumor suppressor. We have, therefore, investigated the organization of the mouse Bim gene, delineating its promoter and splicing, and positioned the gene on both mouse and… CONTINUE READING

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