Gene-specific patterns of coregulator requirements by estrogen receptor-α in breast cancer cells.

@article{Jeong2012GenespecificPO,
  title={Gene-specific patterns of coregulator requirements by estrogen receptor-α in breast cancer cells.},
  author={Kwang Won Jeong and Rajas Chodankar and Daniel J Purcell and Danielle Bittencourt and Michael R Stallcup},
  journal={Molecular endocrinology},
  year={2012},
  volume={26 6},
  pages={955-66}
}
Progesterone receptor (PgR) controls the menstrual cycle, pregnancy, embryonic development, and homeostasis, and it plays important roles in breast cancer development and progression. However, the requirement of coregulators for estrogen-induced expression of the PgR gene has not been fully explored. Here we used RNA interference to demonstrate dramatic differences in requirements of 10 different coregulators for estrogen-regulated expression of six different genes, including PgR and the well… CONTINUE READING
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