Gene-specific control of the TLR-induced inflammatory response.

  title={Gene-specific control of the TLR-induced inflammatory response.},
  author={Simmie L. Foster and Ruslan Medzhitov},
  journal={Clinical immunology},
  volume={130 1},
Toll-like receptors (TLRs) induce a complex inflammatory response that functions to alert the body to infection, neutralize pathogens, and repair damaged tissues. An excessive or persistent inflammatory response can be fatal, so multiple regulatory mechanisms have evolved to control the extent and duration of inflammation. Our current understanding of the control of inflammation is based on negative regulation of TLR signaling. However, TLR-induced genes have diverse functions, and control of… CONTINUE READING

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