Gene single nucleotide polymorphism accumulation improves survival in advanced head and neck cancer patients treated with weekly paclitaxel.

@article{Grau2009GeneSN,
  title={Gene single nucleotide polymorphism accumulation improves survival in advanced head and neck cancer patients treated with weekly paclitaxel.},
  author={Juan Jos{\'e} Grau and Miguel Caballero and Marc Campayo and S M P J Jansa and Maur{\'i}cio Fontana de Vargas and Lluc{\`i}a Alos and M Monzo},
  journal={The Laryngoscope},
  year={2009},
  volume={119 8},
  pages={1484-90}
}
OBJECTIVES/HYPOTHESIS Single nucleotide polymorphisms (SNPs) of certain genes involved in drug metabolism correlate with survival. METHODS We evaluated the presence of SNPs in six genes (CYP2C8, GSTT1, GSTP1, MDR1-57, MDR1-62, and ERCC1) and the response rate (RR), time to progression (TTP), and overall survival (OS) of advanced head and neck cancer patients treated with weekly paclitaxel. RESULTS SNPs in CYP2C8, MDR1-57, and MDR1-62 genes were more frequent than wild-type genes in our… CONTINUE READING