Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

@article{Subramanian2005GeneSE,
  title={Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.},
  author={Aravind Subramanian and Pablo Tamayo and Vamsi K. Mootha and Sayan Mukherjee and Benjamin L. Ebert and Michael A. Gillette and Amanda G. Paulovich and Scott L. Pomeroy and Todd R. Golub and Eric S. Lander and Jill P. Mesirov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 43},
  pages={15545-50}
}
Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe a powerful analytical method called Gene Set Enrichment Analysis (GSEA) for interpreting gene expression data. The method derives its power by focusing on gene sets… CONTINUE READING