Gene set analysis: A step-by-step guide.

@article{Mooney2015GeneSA,
  title={Gene set analysis: A step-by-step guide.},
  author={Michael A. Mooney and Beth Wilmot},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2015},
  volume={168 7},
  pages={517-27}
}
To maximize the potential of genome-wide association studies, many researchers are performing secondary analyses to identify sets of genes jointly associated with the trait of interest. Although methods for gene-set analyses (GSA), also called pathway analyses, have been around for more than a decade, the field is still evolving. There are numerous algorithms available for testing the cumulative effect of multiple SNPs, yet no real consensus in the field about the best way to perform a GSA… CONTINUE READING
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