Gene regulatory potential of nonsteroidal vitamin D receptor ligands.

  title={Gene regulatory potential of nonsteroidal vitamin D receptor ligands.},
  author={Mikael Per{\"a}kyl{\"a} and Marjo Malinen and Karl‐Heinz Herzig and Carsten Carlberg},
  journal={Molecular endocrinology},
  volume={19 8},
The seco-steroid 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] is a promising drug candidate due to its pleiotropic function including the regulation of calcium homeostasis, bone mineralization and cellular proliferation, differentiation, and apoptosis. We report here a novel class of nonsteroidal compounds, represented by the bis-aromatic molecules CD4409, CD4420, and CD4528, as ligands of the 1alpha,25(OH)2D3 receptor (VDR). Taking the known diphenylmethane derivative LG190178 as a… 

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