Gene regulatory network inference using fused LASSO on multiple data sets

@inproceedings{Omranian2016GeneRN,
  title={Gene regulatory network inference using fused LASSO on multiple data sets},
  author={Nooshin Omranian and Jeanne M. O. Eloundou-Mbebi and Bernd Mueller-Roeber and Zoran Nikoloski},
  booktitle={Scientific reports},
  year={2016}
}
Devising computational methods to accurately reconstruct gene regulatory networks given gene expression data is key to systems biology applications. Here we propose a method for reconstructing gene regulatory networks by simultaneous consideration of data sets from different perturbation experiments and corresponding controls. The method imposes three biologically meaningful constraints: (1) expression levels of each gene should be explained by the expression levels of a small number of… CONTINUE READING
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