Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.

@article{Abe2012GeneRV,
  title={Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.},
  author={Haruka Abe and Makoto Okazawa and Shigetada Nakanishi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 22},
  pages={
          8734-9
        }
}
In maturing postnatal cerebellar granule cells, the Etv1/Er81 transcription factor is induced by sequential activity-dependent mechanisms through stimulation of AMPA and NMDA receptors, voltage-dependent Nav1.2 Na(+) channels, and voltage-dependent Ca(2+) channels. Etv1 then up-regulates a battery of maturation genes involved in the cerebellar circuitry. In this process, BDNF is also induced and participates in the up-regulation of these maturation genes. Using cultures of granule cells, we… CONTINUE READING
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