Gene regulation in S. mutans: complex control in a complex environment.

  title={Gene regulation in S. mutans: complex control in a complex environment.},
  author={Evan G Smith and Grace A. Spatafora},
  journal={Journal of dental research},
  volume={91 2},
Dental caries is a chronic infectious disease of multifactorial etiology that derives from the interplay among cariogenic bacteria on the dentition, the host diet, and other environmental exposures. Streptococcus mutans proliferates as a biofilm on the tooth surface, where it obtains nutrients and metabolizes fermentable dietary carbohydrates. The accumulation of lactic acid as a by-product of fermentation results in acidification of the plaque biofilm and demineralization of tooth enamel… CONTINUE READING
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