Gene regulation by voltage-dependent calcium channels.

@article{Barbado2009GeneRB,
  title={Gene regulation by voltage-dependent calcium channels.},
  author={Maud Barbado and Katell Fablet and Michel Ronjat and Michel De Waard},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1793 6},
  pages={
          1096-104
        }
}
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References

SHOWING 1-10 OF 101 REFERENCES
Calcium as a versatile second messenger in the control of gene expression
TLDR
The elevation of intracellular calcium is a major effector of stimulus‐induced physiological change in a variety of cell types and frequently involves the activation of gene expression.
Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway
TLDR
A functional knock-in technique to investigate the features of LTCs that specifically couple them to the signaling pathways that regulate gene expression found that an isoleucine-glutamine motif in the carboxyl terminus of the LTC that binds Ca2-calmodulin (CaM) is critical for conveying the Ca2+ signal to the nucleus.
CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation–transcription coupling
TLDR
It is found that signaling strength is steeply dependent on depolarization, with sensitivity far greater than hitherto recognized, and data indicate that Ca2+/CaM-dependent protein kinase II acting near the channel couples local Ca2+.
Calcium oscillations increase the efficiency and specificity of gene expression
TLDR
It is reported that oscillations reduce the effective Ca2+ threshold for activating transcription factors, thereby increasing signal detection at low levels of stimulation and providing direct evidence that [Ca2+]i oscillations increase both the efficacy and the information content of Ca2+, leading to gene expression and cell differentiation.
Calcium channel activation stabilizes a neuronal calcium channel mRNA
TLDR
A calcium-dependent pathway in neurons that regulates expression levels of the α1B subunit and N channel current is identified and may represent a form of modulation of N-channel levels that does not require changes in gene transcription.
Structural and functional diversity of voltage-activated calcium channels.
TLDR
Several avenues of research are summarized that should provide significant clues about the structural features involved in the biophysical and functional diversity of voltage-dependent Ca2+ channels.
Calcium signaling in neurons: molecular mechanisms and cellular consequences.
TLDR
Calcium differentially affects processes that are central to the development and plasticity of the nervous system, including activity-dependent cell survival, modulation of synaptic strength, and calcium-mediated cell death.
Ca2+-operated transcriptional networks: molecular mechanisms and in vivo models.
TLDR
Well-known and recently identified proteins that sense and decode the calcium signal and are key elements in the nucleus to regulate the activity of various transcriptional networks are presented.
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