Gene regulation by tetracyclines.

  title={Gene regulation by tetracyclines.},
  author={Christian Berens and Wolfgang Hillen},
  journal={Genetic engineering},
Gene regulation by tetracyclines has become a widely-used tool to study gene functions in pro- and eukaryotes. This regulatory system originates from Gram-negative bacteria, in which it fine-tunes expression of a tetracycline-specific export protein mediating resistance against this antibiotic. This review attempts to describe briefly the selective pressures governing the evolution of tetracycline regulation, which have led to the unique regulatory properties underlying its success in manifold… CONTINUE READING

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