Gene regulation by Sp1 and Sp3.

@article{Li2004GeneRB,
  title={Gene regulation by Sp1 and Sp3.},
  author={Lin Li and Shihua He and Jian-Min Sun and James R. Davie},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2004},
  volume={82 4},
  pages={
          460-71
        }
}
The Sp family of transcription factors is united by a particular combination of three conserved Cys2His2 zinc fingers that form the sequence-specific DNA-binding domain. Within the Sp family of transcription factors, Sp1 and Sp3 are ubiquitously expressed in mammalian cells. They can bind and act through GC boxes to regulate gene expression of multiple target genes. Although Sp1 and Sp3 have similar structures and high homology in their DNA binding domains, in vitro and in vivo studies reveal… CONTINUE READING
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