Gene regulation at the single-cell level.

@article{Rosenfeld2005GeneRA,
  title={Gene regulation at the single-cell level.},
  author={Nitzan Rosenfeld and Jonathan W. Young and Uri Alon and Peter S. Swain and Michael B. Elowitz},
  journal={Science},
  year={2005},
  volume={307 5717},
  pages={1962-5}
}
The quantitative relation between transcription factor concentrations and the rate of protein production from downstream genes is central to the function of genetic networks. Here we show that this relation, which we call the gene regulation function (GRF), fluctuates dynamically in individual living cells, thereby limiting the accuracy with which transcriptional genetic circuits can transfer signals. Using fluorescent reporter genes and fusion proteins, we characterized the bacteriophage… CONTINUE READING
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