Gene regulation and DNA damage in the ageing human brain

@article{Lu2004GeneRA,
  title={Gene regulation and DNA damage in the ageing human brain},
  author={Tao Lu and Ying Pan and S. Kao and Cheng Li and I. Kohane and J. Chan and B. Yankner},
  journal={Nature},
  year={2004},
  volume={429},
  pages={883-891}
}
The ageing of the human brain is a cause of cognitive decline in the elderly and the major risk factor for Alzheimer's disease. The time in life when brain ageing begins is undefined. Here we show that transcriptional profiling of the human frontal cortex from individuals ranging from 26 to 106 years of age defines a set of genes with reduced expression after age 40. These genes play central roles in synaptic plasticity, vesicular transport and mitochondrial function. This is followed by… Expand
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