Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome.

Abstract

Among a collection of 74 aprt mutations induced by treatment of plateau phase Chinese hamster ovary CHO cells with the radiomimetic DNA double-strand cleaving agent neocarzinostatin, nine were large-scale rearrangements. Molecular analysis indicated that all nine were highly conservative, non-homologous reciprocal exchanges, most of which were… (More)

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@article{Wang2002GeneRI, title={Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome.}, author={Peng Wang and Jae Wan Lee and Yin Yu and Kristi C. Turner and Ying Zou and Colleen K. Jackson-Cook and Lawrence F. Povirk}, journal={Nucleic acids research}, year={2002}, volume={30 12}, pages={2639-46} }