Gene rearrangements and chromosomal translocations in T cell lymphoma — diagnostic applications and their limits


The diversity of the T cell receptor (TCR) repertoire is established for individual T lymphocytes by developmentally regulated gene rearrangements and shaped by predominantly intrathymic selection procedures. TCR gene probes in Southern blot experiments and TCR primers for the polymerase chain reaction (PCR) help to distinguish polyclonal from abnormal… (More)
DOI: 10.1007/BF00191340

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