Gene rearrangement studies in the diagnosis of primary systemic and nodular primary localized cutaneous amyloidosis.

@article{Gruenewald1991GeneRS,
  title={Gene rearrangement studies in the diagnosis of primary systemic and nodular primary localized cutaneous amyloidosis.},
  author={Kurt Gruenewald and Norbert Sepp and K Weyrer and Karl Lhotta and Hans Feichtinger and Guenther Konwalinka and Stephen M Breathnach and Helmut Hintner},
  journal={The Journal of investigative dermatology},
  year={1991},
  volume={97 4},
  pages={693-6}
}
Difficulties may arise in the diagnosis of patients with clinical features suggestive of plasma cell dyscrasia-related amyloidosis (amyloidosis L), but without evidence of a paraprotein. We have employed gene rearrangement methodology to demonstrate the clonality of bone marrow cells not only in a patient with myeloma-associated systemic amyloidosis, but also in a patient with "primary" systemic amyloidosis without overt myeloma or a detectable paraprotein. Furthermore, we have shown the… CONTINUE READING

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