Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction.

@article{Trainor1991GeneRI,
  title={Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction.},
  author={Kevin J. Trainor and Michael J. Brisco and Judy H. C. Wan and S Neoh and Scott A Grist and Alec A. Morley},
  journal={Blood},
  year={1991},
  volume={78 1},
  pages={192-6}
}
Gene rearrangement and monoclonality have been detected in normal cells and in lymphoproliferative disease by using the polymerase chain reaction and primers for the V and J regions of the Ig heavy chain gene or T-cell receptor gamma-chain gene. Using the Ig primers monoclonality was detected in 20 of 20 normal B-lymphocyte clones and in 39 of 52 cases of various types of B-lymphoproliferative disease, but not in 11 cases of T-lymphoproliferative disease. Using the T-cell receptor primers… CONTINUE READING

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