Gene promoter hypermethylation in oral rinses of leukoplakia patients--a diagnostic and/or prognostic tool?

@article{Lpez2003GenePH,
  title={Gene promoter hypermethylation in oral rinses of leukoplakia patients--a diagnostic and/or prognostic tool?},
  author={Mar{\'i}a Lilia Dom{\'i}nguez L{\'o}pez and Jos{\'e} Manuel Aguirre and Nerea Cuevas and M{\'o}nica Anzola and Juan Videgain and J Aguirregaviria and Marian Mart{\'i}nez de Pancorbo},
  journal={European journal of cancer},
  year={2003},
  volume={39 16},
  pages={2306-9}
}
Leukoplakia is the most frequent oral precancerous lesion and shows a variable rate of malignant transformation. We hypothesised that the detection of molecular alterations, like the promoter hypermethylation of DNA, in oral cytological samples from patients at risk of developing primary or recurrent tumours could be a valuable diagnostic and prognostic tool in the management of these lesions. Two groups of patients with differing risks of developing oral squamous cell carcinoma (OSCC) were… CONTINUE READING