Gene-promoter hypermethylation as a biomarker in lung cancer


Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify… (More)
DOI: 10.1038/nrc1432


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