Gene profiling of human fetal and adult adrenals.

  title={Gene profiling of human fetal and adult adrenals.},
  author={William E. Rainey and Bruce Richard Carr and Zi Ning Wang and C. Richard Parker},
  journal={The Journal of endocrinology},
  volume={171 2},
The mechanisms that lead to the steroidogenic differences in the human fetal adrenal (HFA) and adult adrenal gland are not known. However, gene expression clearly plays a critical role in defining their distinct steroidogenic and structural phenotypes. We used DNA microarrays to compare expression levels of several thousand transcripts between the HFA and adult adrenal gland. Total RNA was isolated from 18 HFA and 12 adult adrenal glands. Samples of total RNA were used to make five pools of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations

Maternal-fetal conflict, genomic imprinting and mammalian vulnerabilities to cancer.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2015


Publications referenced by this paper.
Showing 1-10 of 17 references

Mitogenic action, regulation, and localization of insulin-like growth factors in the human fetal adrenal gland.

The Journal of clinical endocrinology and metabolism • 1993
View 12 Excerpts
Highly Influenced

Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor mRNA levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells

D Lallemand, A Penhoat, +4 authors JM Saez
Journal of Clinical Endocrinology and Metabolism • 1996
View 1 Excerpt

Similar Papers

Loading similar papers…